Efficacy of Lasers Treatment of Exposed Pulps to Stimulate Healing: A Systematic Review and Meta-Analysis

Abstract Objective: The present systematic review and meta-analysis aimed at evaluating the efficacy of laser's treatment of exposed pulps to stimulate healing. Material and Methods: MEDLINE, PubMed, Cochrane Library, Embase, ISI, Google Scholar have been searched as the electronic databases for performing systematic literature between 2005 to 2019. Searches were performed with MESH terms. The quality of the studies included was assessed using the Critical Appraisal Skills Program checklist. For Data extraction, two reviewers blind and independently extracted data from the abstract and full text of the studies included. Moreover, the fixed-effect model's odds ratio for a 95% confidence interval (CI) was calculated. Random effects were used to deal with potential heterogeneity, and I2 showed heterogeneity. The meta-analysis and forest plots have been evaluated using the Comprehensive Meta-Analysis Stata. Results: Five studies (3 RCTs and 2 animal studies) were included in this study. The Odds Ratio was 1.90 (95% CI 1.39-2.42; p=0.00); there was a statistically significant difference between the laser and the control groups (p=0.00). Conclusion: The success rate of laser treatment for exposed pulps is higher than mineral trioxide aggregate, resin, calcium hydroxide and resin-modified glass-ionomer cement. The exact mechanism of this effect has not yet been determined; further research on lasers' impact on exposed pulps treatment is required.

Hyalinization and Molecular Pathways Involved in Orthodontic Tooth Movement: A Systematic Review and Meta-Analysis

Abstract Objective: To systematically review the hyalinization of experimental tooth movement in humans and animals. Material and Methods: The electronic databases of MEDLINE, PubMed, Cochrane Library, Embase, Institute for Scientific Information, and Google Scholar were searched for performing a systematic review of the related literature published until 2019. Moreover, Endnote X9 software was utilized to manage electronic titles. The searches were fulfilled using keywords of "hyalinization," "orthodontic tooth movement" OR "OTM" AND "periodontal ligament" OR "PDL," "molecular pathways," AND "mechanical cell." Therefore, this systematic review was conducted based on the key consideration of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: Forces ranged between 2.3 and 50 CN had been applied. According to the research design, incisors had been included in two experiments, whereas maxillary molars had been displaced by tipping forces in another rat examination. However, a majority of investigations had stated that hyalinization had firstly appeared within the first 24 hours. Moreover, the amount of prostaglandin-end peroxide synthase 2 (PTGS2) had been positively related to force term and size utilizing Western blotching. As PTGS2 had been included in the prostaglandin E2 (PGE2) metabolism, the up-regulation of PTGS2 gene expression could be connected with that of PGE2 emission. Conclusion: Gene expression in connection with force term and size and also the first signalling pathways were recognized utilizing protein-protein interactions (PPIs).

Management of the maxillary sinus complications after dental implantation: a systematic review and meta-analysis / Tratamento das complicações do seio maxilar após cirurgia de implante dentário: Revisão Sistemática e Meta-Análise

Background and aim: Endoscopic sinus surgery owing to its satisfactory prognosis and low complication is considered as the first line of surgical procedure. Implant failure is often reported despite efforts in recent years. The purpose of this study was to review the factors leading to side effects in dental implantation of the maxillary sinus. Material and Methods: The systematic search was performed on electronic databases of MEDLINE, PubMed, Cochrane Library, Embase, ISI, Google scholar to find corresponding articles regarding dental literature during 2010 to 2019. Electronic title management was carried out by Endnote X9 software. Searches were based on the keywords of "dental implants", "Implants"," dental"," maxilla", "sinusitis". Results: The searched potentially relevant titles and abstracts were related to 294 articles, 104 of which were excluded due to lack of study inclusion criteria. At last, 11 articles were included into the final analysis. Postoperative sinusitis was found in 78 patients within 9 articles among 1195 patients. The implant failure was reported in 136 cases and the sinus membrane perforation in 185 sinuses within 11 articles among 1372 sinus lift procedures. Conclusion: The findings showed that the risk factors of sinusitis after implant surgery were Schneiderian membrane rupture and preoperative sinusitis, as well as smoking and residual bone height were the parameters elevating the dental implant failure risk. (AU)

Justificativa e objetivo: A cirurgia endoscópica do seio maxilar, devido ao seu prognóstico satisfatório e baixa complicação, é considerada a primeira opção cirúrgica. A falha do implante é frequentemente relatada, apesar dos esforços realizados nos últimos anos. O objetivo deste estudo foi revisar os fatores que levaram a efeitos colaterais no implante dentário do seio maxilar. Material e Métodos: A busca sistemática foi realizada nas bases de dados eletrônicas do MEDLINE, PubMed, Cochrane Library, Embase, ISI, Google Scholar para encontrar artigos correspondentes sobre literatura odontológica no período de 2010 a 2019. O gerenciamento eletrônico de títulos foi realizado pelo software Endnote X9. As pesquisas foram baseadas nas palavras-chave "implantes dentários", "implantes", "dentário", "maxila", "sinusite". Resultados: Os títulos e resumos potencialmente relevantes pesquisados foram relacionados a 294 artigos, 104 dos quais foram excluídos por falta de critérios de inclusão no estudo. Por fim, 11 artigos foram incluídos na análise final. Sinusite pós-operatória foi encontrada em 78 pacientes em 9 artigos entre 1195 pacientes. A falha do implante foi relatada em 136 casos e a perfuração da membrana sinusal em 185 seios, em 11 artigos, entre 1372 procedimentos de elevação sinusal. Conclusão: Os achados mostraram que os fatores de risco para sinusite após cirurgia de implante foram ruptura da membrana Schneideriana e sinusite pré-operatória, assim como tabagismo e altura óssea residual, os quais foram considerados parâmetros que elevaram o risco de falha do implante dentário. (AU)